NCT03826693

Efficacy of Nitrous Oxide in OCD: Pilot Study

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.

Detailed description

Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder characterized by recurrent intrusive thoughts and associated compulsive behaviors that is estimated to affect more than 3 million individuals in the US each year. This study seeks to explore whether a single inhalation of nitrous oxide gas may bring about rapid symptom relief in OCD.

Conditions

• Obsessive-Compulsive Disorder

Interventions

Type	Name	Description
DRUG	Nitrous Oxide	OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes.
DRUG	Nitrogen	OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.

Timeline

• Start date: 2021-04-17
• Primary completion: 2026-09-01
• Completion: 2027-10-01
• First posted: 2019-02-01
• Last updated: 2025-08-27

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study