NCT03810950

Psychobiology of Stress and Alcohol Craving

Physiological, Neural and Behavioral Correlates of Psychosocial Stress and Alcohol Craving

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Central Institute of Mental Health, Mannheim · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In this feasibility study the investigators are using a setup of stress-related body sensors including established as well as innovative sensor-based measures to identify predictor profiles for alcohol-related behavioral and neural measures in Alcohol Use Disorder (AUD). Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting.

Detailed description

The long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting. In patients with Alcohol Use Disorder (AUD) stress exposure is known to affect craving, cue-reactivity and relapse risk. Here, the investigators aim to identify stress- and alcohol cue-related physiological markers in a lab experiment to assess interactions between acute psychological stress exposure and alcohol cue-exposure regarding their effects on alcohol craving and related markers (attentional bias to alcohol-cues, implicit association task, neural cue-reactivity). In addition to applying established stress-related markers (cortisol in saliva, heart-rate variability, systolic blood pressure and electrodermal activity), the investigators will integrate innovative measures currently under investigation (e.g. voice stress analysis) to identify whether these additional parameters increase the predictive significance.

Conditions

• Alcohol Use Disorder
• Stress Reaction
• Social Stress
• Craving
• Behavior

Interventions

Type	Name	Description
BEHAVIORAL	Trier Social Stress Test	Test to induce high levels of acute social stress, including actors and a faked exam situation
BEHAVIORAL	Reading Newspaper	Participants read newspaper
BEHAVIORAL	Barlab-Exposure	Participants are exposed to a bar situation with different sorts of alcohol available. They sniff at water and at one alcoholic drink.

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2019-01-22
• Last updated: 2024-03-29

Locations

1 site across 1 country: Germany