NCT03809182

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Effect of Dexmedetomidine on Postoperative Glucose Levels and Insulin Secretion Patterns in Obese Patients With Impaired Glucose Tolerance.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Pontificia Universidad Catolica de Chile · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study investigated the effect of dexmedetomidine in obese patients undergoing bariatric surgery.

Detailed description

A prospective, double-blind, randomized controlled trial was performed. Consenting obese adult patients with impaired glucose tolerance, undergoing bariatric surgery, were randomized, by a computer, to receive placebo (0.9% Sodium-chloride) or dexmedetomidine 1 ug/kg bolus in 10 minutes followed by an infusion of 0.5 ug/kg/h until the end of surgery. Baseline HgbA1c, glucose, and insulin plasmatic levels were measured. Subsequently, glucose and insulin levels were taken every 2 hours during the first 12 hours from the onset of the drug infusion. Intraoperative fentanyl and postoperative morphine consumption, pain score, the occurrence of emesis, and postoperative sedation levels were recorded as secondary outcomes.

Conditions

• Bariatric Surgery Candidate
• Glucose Intolerance
• Insulin Resistance

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	A bolus of 1ug/kg in 10 minutes, followed by an infusion of 0.5ug/kg/h until the end of surgery.
DRUG	0.9% Sodium-chloride	The same infusion rate used in the dexmedetomidine group.
DRUG	Fentanyl	Intraoperative fentanyl was given in case of 25% increment in the blood pressure and/or heart rate in comparison to baseline (previous anesthesia induction).
DRUG	Morphine Sulfate	Boluses of 3mg of intravenous morphine were given in the postoperative acute care unit. Once the pain score was equal or less than 3/10 the patient-controlled analgesia pumps were installed and the patients were discharged to their room.

Timeline

• Start date: 2012-09-27
• Primary completion: 2013-07-25
• Completion: 2013-07-25
• First posted: 2019-01-18
• Last updated: 2020-10-01
• Results posted: 2020-10-01