NCT03806829

The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

Pilot Study: The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: University of the Highlands and Islands · Academic / Other
• Sex: All
• Age: 50 Years – 65 Years
• Healthy volunteers: Accepted

Summary

High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress. Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.

Conditions

• Endothelial Dysfunction

Interventions

Type	Name	Description
OTHER	Water	250 ml
OTHER	Red Wine	250 ml
OTHER	Green Tea	250 ml
OTHER	Orange Juice	250 ml

Timeline

• Start date: 2018-06-06
• Primary completion: 2018-07-31
• Completion: 2018-07-31
• First posted: 2019-01-16
• Last updated: 2019-01-16

Locations

1 site across 1 country: United Kingdom