NCT03786146

Changes in Retinal Nerve Fiber Layer Thickness Detected by OCT in Diabetic Retinopathy After Panretinal Photocoagulation

Changes in Retinal Nerve Fiber Layer Thickness Detected by Optical Coherence Tomography in Diabetic Retinopathy After Panretinal Photocoagulation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: —

Summary

Panretinal photocoagulation reduces the risk of visual loss by 50% in patients with diabetic retinopathy. It is recognized that laser expansion into the retina may be associated with photoreceptor loss, retinal pigment epithelial hypertrophy and visual field loss. Panretinal photocoagulation can cause alteration in retinal vascular permeability therefore, retinal thickness may be increased including retinal nerve fiber layer. On the contrary, it can damage retinal cells including ganglion cells, which may decrease the retinal nerve fiber layer thickness in the latter follow up period. Peripapillary retinal nerve fiber layer can be measured by optical coherence tomography which is a non-invasive technique for obtaining high resolution cross sectional images of a tissue.

Detailed description

Pre laser assessment: * Assessment of medical and family history * Refraction and best corrected visual acuity * Anterior segment examination using binocular slit lamp bi-microscopy. * Posterior segment examination. * OCT scan of peripapillary area Post laser assessment ( at 1,3 and 6 months): * Refraction and best corrected visual acuity. * Anterior segment examination using binocular slit lamp bi-microscopy. * Posterior segment examination. * OCT scan of peripapillary area.

Conditions

• Retinal Disease

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-11-01
• Completion: 2019-12-01
• First posted: 2018-12-24
• Last updated: 2018-12-24