NCT03784755

Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer

A Randomized Phase III Trial of Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer [PLATON]

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 409 (actual)
• Sponsor: Canadian Cancer Trials Group · Network
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effects of ablative therapy (radiation or surgery) to all sites of disease combined with standard treatments on prostate cancer, compared to the standard or usual treatments used to treat this disease.

Detailed description

The standard or usual treatment for this disease is systemic therapy, which includes androgen deprivation therapy (ADT) with or without chemotherapy or hormone therapy. Additionally, for some patients with specific disease features, standard treatment may also include ablative treatment (radiation or surgery) of the prostate gland if this was not completed prior to enrolling into this study. Ablative Therapy is a procedure used to destroy cancer cells and tissue. In this study Stereotactic Body Radiation Therapy (SBRT) or surgery will be used to destroy prostate cancer metastases. It is not clear if ablative therapy (SBRT or surgery) to all sites of disease used in combination with standard systemic therapy can offer better results than standard treatment alone.

Conditions

• Prostate Cancer Metastatic

Interventions

Type	Name	Description
RADIATION	Ablative Radiation Therapy	Undergo stereotactic radiotherapy and/or surgery to all sites of disease (oligometastases and primary prostate if previously untreated).
OTHER	Standard of care	Patients continue to receive their current planned systemic therapy at the discretion of the treating physician

Timeline

• Start date: 2019-11-15
• Primary completion: 2032-12-31
• Completion: 2033-07-30
• First posted: 2018-12-24
• Last updated: 2026-03-27

Locations

18 sites across 1 country: Canada