NCT03773497

Bioavailability of Phytonutrients From Novel Preparations of Broccoli

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: USDA Beltsville Human Nutrition Research Center · Federal
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to determine the effects of different methods of broccoli preparation on levels of urinary glucosinolate metabolites. The secondary objective is to determine the effects of different methods of broccoli preparation on levels of plasma carotenoids.

Detailed description

Consumption of Brassica vegetables (which include broccoli, cabbage, and kale) is inversely associated with the incidence of several cancers, including cancers of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassica vegetables are a good source of many nutrients including glucosinolates and carotenoids. Glucosinolates are sulfur-containing compounds that are converted to bioactive metabolites by an enzyme called myrosinase, which is released when the vesicles containing myrosinase are ruptured by chewing or cutting. These bioactive compounds are considered to be active agents for cancer prevention. Their ability to reduce risk of cancer may derive in part from their ability to modulate foreign-substance metabolizing enzymes, which include enzymes called Phase I cytochrome P450s and Phase II enzymes. Carotenoids may also have a role in cancer prevention and other health benefits including reducing age-related macular degeneration, and therefore merit research to reveal factors that affect their presence in the body. The primary aim of this study is to investigate how various preparations of broccoli impact levels of these healthful nutrients in humans.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	Common Snack Combination	Combination of Chips, Pretzels, and Popcorn.
OTHER	Cheesy Broccoli Snack	Oven-roasted, freeze-dried, cheese flavored broccoli
OTHER	Cheesy Broccoli with Daikon Radish Snack	Oven-roasted, freeze-dried, cheese flavored broccoli with Daikon radish powder
OTHER	Uncooked Broccoli Snack	Uncooked, freeze-dried broccoli with ranch-type dip

Timeline

• Start date: 2019-04-16
• Primary completion: 2019-06-28
• Completion: 2019-06-28
• First posted: 2018-12-12
• Last updated: 2019-09-03

Locations

1 site across 1 country: United States