NCT03771066

Bisphenol A and Muscle Insulin Sensitivity

Randomized Trial Examining Oral Consumption of Bisphenol A on Type 2 Diabetes Risk Markers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: California Polytechnic State University-San Luis Obispo · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Detailed description

Evidence linking bisphenol A exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol A to type 2 diabetes remains unclear. The investigator's preliminary data suggests that in young adults, single oral BPA consumption significantly decreased glucose, insulin, and C-Peptide responses to an oral glucose tolerance test, suggesting that immediate consumption of bisphenol A has an effect on muscle insulin sensitivity, hepatic glucose suppression and/or digestion and absorption to lower blood glucose, insulin, and C-Peptide concentrations. The present experimental study evaluating the effects of bisphenol A over several days on the pathogenesis of type 2 diabetes will directly assess each of these potential mechanisms using gold standard measures (euglycemic hyperinsulinemic clamp technique and hepatic glucose suppression with glucose stable isotope infusion, and fecal microbiota).

Conditions

• Insulin Sensitivity
• Glucose Metabolism Disorders
• Microtia

Interventions

Type	Name	Description
BEHAVIORAL	bisphenol A	Vanilla wafer cookie with bisphenol A administered
BEHAVIORAL	Placebo	Vanilla wafer cookie with no bisphenol A

Timeline

• Start date: 2019-01-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2018-12-10
• Last updated: 2024-07-08

Locations

1 site across 1 country: United States