NCT03764748

Washed Microbiota Transplantation for Tourette's Syndrome

Efficacy and Safety of Washed Microbiota Transplantation for Tourette's Syndrome

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: The Second Hospital of Nanjing Medical University · Academic / Other
• Sex: All
• Age: 6 Years – 17 Years
• Healthy volunteers: Accepted

Summary

This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).

Detailed description

Emerging scientific data support the significant role of microbiota in the modulation of the central nervous system. The reconstitution of gut microbiota might be a potential option to treat Tourette's syndrome (TS). FMT has been reported to be a highly effective therapy to restore the gut microbiota dysbiosis by transferring gut microbiota from healthy donors to patients. The newly improved methodology of FMT based on the automatic washing process and the related delivering consideration was named as washed microbiota transplantation (WMT) by the FMT-standardization study group. FMT has shown treatment potential in several gut-brain axis-related disorders, such as amyotrophic lateral sclerosis and Parkinson's disease, promoting us to investigate its treatment potential for Tourette's syndrome. In this study, investigators aimed to evaluate the efficacy of WMT for Tourette's syndrome and its comorbidities using specialized questionnaires for Tourette's syndrome and investigate the underlying mechanism.

Conditions

• Tourette Syndrome

Interventions

Type	Name	Description
DRUG	Washed Microbiota Transplantation	The prepared microbiota suspension was infused into the participates' lower gut.

Timeline

• Start date: 2024-04-17
• Primary completion: 2027-10-31
• Completion: 2027-10-31
• First posted: 2018-12-05
• Last updated: 2024-08-19

Locations

2 sites across 1 country: China