NCT03761381

OCT Angiography and NRAI in Dementia

Using Optical Coherence Tomography and Noninvasive Retinal Amyloid Imaging to Capture Retinal Changes Associated With Dementia

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Accepted

Summary

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.

Conditions

• Alzheimer Disease
• Dementia
• Mild Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	Optical Coherence Tomography Angiography (OCTA) Imaging	Optical coherence tomography is a non-invasive imaging technology that provides cross-sectional images of tissues in micron-scale resolution. The angiography component of this device allows for evaluation of blood vessel and blood flow changes in the eye. The Solix device with AngioVue software will be used to detect these blood vessel and flow changes as well as protein deposits in the retinal layers.
DEVICE	Noninvasive Retinal Amyloid Imaging (NRAI)	The Spectralis will be used for NRAI. This system uses a special light source and optical filters to detect fluorescence of amyloid proteins in the eye.

Timeline

• Start date: 2018-09-14
• Primary completion: 2026-12-01
• Completion: 2027-12-01
• First posted: 2018-12-03
• Last updated: 2025-09-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study