NCT03742960

Sleep Subtypes in Adolescent Depression

Sleep Subtypes in Adolescent Depression: Sleep Physiology and Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 71 (actual)
• Sponsor: University of Bern · Academic / Other
• Sex: All
• Age: 14 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare sleep neurophysiology and behavior in adolescents with MDD with hypersomnia (MDD-HYP) and insomnia (MDD-INS) with healthy controls (HC). In addition, the investigators will test the efficacy of a simple behavioral sleep restriction on mood and sleep in their sample.

Detailed description

The World Health Organization has identified depression as the leading cause of burden of disease amongst young people. Subjective sleep complaints are often a core symptom of depression and highly prevalent with 60-90% of depressed adolescents suffering from disrupted sleep. This sleep disruption often takes the form of insomnia (e.g., difficulty falling or staying asleep, or waking too early) or hypersomnia (prolonged sleep episodes or excessive daytime sleepiness). The aim of the trial is to examine the efficacy of a simple behavioral sleep restriction two weeks in duration on mood and sleep in adolescents ages 14 to 17 years with and without major depressive disorder. During this period sleep is objectively measured using actigraphy and monitor mood using self-report. The results of the study will inform whether a simple behavioral sleep restriction beneficially impacts mood and sleep.

Conditions

• Major Depressive Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Behavioral Sleep Restriction	Participants will be instructed to go to bed 30 minutes later than their usual bedtime. On the other hand, wake up time will be unchanged resulting a nightly sleep restriction of 30 minutes. This protocol will be followed for two weeks.

Timeline

• Start date: 2019-04-24
• Primary completion: 2023-07-01
• Completion: 2023-07-01
• First posted: 2018-11-15
• Last updated: 2023-11-30

Locations

1 site across 1 country: Switzerland