Trials / Completed
CompletedNCT03733743
Day-night Rhythm in Muscle Metabolism of Prediabetics
Day-night Rhythm in Muscle Metabolism of Prediabetic Subjects
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 12 (actual)
- Sponsor
- Maastricht University · Academic / Other
- Sex
- Male
- Age
- 40 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
This study evaluates the existence of a day-night rhythm in skeletal muscle energy metabolism in prediabetic subjects. Subjects will stay at the research facility for 44 hours with a standardized living protocol during which several measurements of skeletal muscle and whole body energy metabolism will be performed.
Detailed description
Recent evidence from both observational and experimental studies indicates that disobedience of a normal day-night rhythm negatively influences metabolic and cardiovascular health, possibly leading to obesity and type 2 diabetes mellitus (T2DM). An important hallmark of obesity and T2DM is a decreased skeletal muscle mitochondrial function. Interestingly, recent research indicates that also skeletal muscle mitochondrial function is under the influence of a day-night rhythm. In this study, the presence of a day-night rhythm in skeletal muscle energy metabolism (in particular mitochondrial function) of overweight prediabetic participants will be investigated. During this study, subjects will stay at the research unit for 44 hours, with standardized meals and sleeping time. Five muscle biopsies (v. lateralis) and frequent blood draws will be taken. In addition, indirect calorimetry measurements will be performed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Standardized living protocol | Subjects stay at the research facility for 44 hours and adhere to a standard sleeping, eating and activity protocol. During this protocol, multiple measurements will be performed including skeletal muscle biopsies (m. vastus lateralis), blood draws, indirect calorimetry and MRS measurements. |
Timeline
- Start date
- 2018-07-09
- Primary completion
- 2019-03-20
- Completion
- 2019-03-29
- First posted
- 2018-11-07
- Last updated
- 2019-08-16
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT03733743. Inclusion in this directory is not an endorsement.