NCT03727334

Offsetting Hippocampal Degeneration in m-sTBI

Offsetting Hippocampal Degeneration in Moderate to Severe TBI

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain structures.

Detailed description

The purpose of this study is to establish the feasibility of a novel intervention, and explore biomarker predictors of neurodegeneration and response to the proposed intervention. This 16 week intervention utilises allocentric spatial navigation tasks to improve memory and counteract hippocampal neurodegeneration. This intervention will be administered in combination with neuropsychological assessments, MR imaging, and the analysis of genomic variants at two time points; 7 months post-TBI and 12 months post-TBI.

Conditions

• Traumatic Brain Injury
• Degeneration
• Memory; Loss, Mild, Following Organic Brain Damage

Interventions

Type	Name	Description
BEHAVIORAL	Online Spatial Navigation Training	Participants complete training tasks that test their spatial navigational abilities, cognitive map formation, and pattern separation. These training tasks involve map drawing, vector mapping, proximity judgments, and navigating with blocked routes.

Timeline

• Start date: 2019-07-25
• Primary completion: 2023-07-01
• Completion: 2024-07-01
• First posted: 2018-11-01
• Last updated: 2023-05-09

Locations

2 sites across 1 country: Canada