Trials / Completed
CompletedNCT03726918
Identification of New Predictive Osseointegration Bio-Markers of the Prosthetic Implant in Patients With OsteoArthritis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 9 (actual)
- Sponsor
- Istituto Ortopedico Rizzoli · Academic / Other
- Sex
- All
- Age
- 40 Years
- Healthy volunteers
- —
Summary
The study involves the isolation and cellular, molecular and proteomic characterization of synoviocytes, osteoblasts and chondrocytes from tissue samples obtained from patients undergoing surgery of endo or arthroplasty for osteoarthritis (Experimental Group) or interventions for other causes such as for example periarticular fracture requiring the implantation of a prosthesis (Control Group)
Detailed description
The study involves the isolation and cellular, molecular and proteomic characterization of synoviocytes, osteoblasts and chondrocytes from tissue samples obtained from patients undergoing surgery of endo or arthroplasty for osteoarthritis (Experimental Group) or interventions for other causes such as for example periarticular fracture requiring the implantation of a prosthesis (Control Group) Deeper analysis of micro Ribo Nucleic Acid (RNA) and Non Coding RNA expressed by the synoviocytes, osteoblasts and chondrocytes will be performed in order to understand their possible involvement in pathways of osteogenic differentiation, through suitable experimental in vitro models of co-cultures. In particular, investigators will focus on the cross-talk between synoviocytes and osteoblasts, cell populations involved in the post-surgical articular microenvironment and on which the osteointegration process of the joint prosthesis depends.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Surgery for implantation of a prosthesis | Analysis of micro Ribo Nucleic Acid (RNA) expressed by the synoviocytes, osteoblasts and chondrocytes |
Timeline
- Start date
- 2018-12-14
- Primary completion
- 2020-06-20
- Completion
- 2020-06-20
- First posted
- 2018-11-01
- Last updated
- 2021-08-05
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT03726918. Inclusion in this directory is not an endorsement.