NCT03722095

Research on the Effects of Combined Neurostimulation Protocols on Stress

The Effects of Preconditioning Theta Burst Stimulation With Transcranial Direct Current Stimulation on Stress Regulation in Healthy Controls: a Double-blind Sham-controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: University Ghent · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.

Detailed description

Transcranial Direct Current Stimulation (tDCS) will be combined with intermittent Theta Burst Stimulation (iTBS) in order to maximize the effects coming from each of the techniques on their own. A group of 74 healthy participants wil be submitted to two different stimulation protocols (sham tDCS + active iTBS and active tDCS + active iTBS) with one-week in between and results on stress reactivity will be examined. In order to improve therapeutic protocols, this study with healthy participants is a crucial first step in order to further conduct clinical studies with psychiatric samples.

Conditions

• Stress Reaction
• Stress Related Disorder
• Major Depressive Disorder

Interventions

Type	Name	Description
DEVICE	active tDCS	A current of 2 milliampère (mA) through electrodes of 5x5cm.
DEVICE	sham tDCS	Similar set-up as in the active tDCS, but stimulation is too short to cause any effects.
DEVICE	iTBS	54 cycles with 10 bursts of 3 pulses, train duration of 2 seconds and intertrain intervals of 6 seconds, results in 1620 pulses at 110% resting motor threshold.

Timeline

• Start date: 2018-10-29
• Primary completion: 2020-10-31
• Completion: 2020-10-31
• First posted: 2018-10-26
• Last updated: 2021-11-30

Locations

1 site across 1 country: Belgium