NCT03712917

Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine

Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine: A Randomised Parallel Group Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 15 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Background: Preventive drug therapy in migraine aims to reduce the attack frequency, severity and duration of headache. Flunarizine and topiramate are widely used in the prevention of migraine attacks. Greater occipital nerve block (GONB) is an alternative treatment option for the prophylactic treatment of migraine. In this study, investigators compared the effectiveness of GONB, topiramate, and flunarizine in terms of reduction in post-treatment VAS scores and attack frequencies in patients with episodic migraine in a four-week period. Material and Methods: At least one hundred and twenty migraine patients are aimed to be randomly divided into three treatment groups, namely flunarizine (n=40, estimated), topiramate (n=40, estimated) and GONB (n=40, estimated). The patients will be followed up for four weeks and the attack frequencies and VAS scores will be recorded weekly. At the end of the fourth week, the response rates based on 50% and 75% or more reduction in the VAS scores and attack frequencies will be calculated. Group-wise comparisons will be assessed statistically.

Conditions

• Migraine

Interventions

Type	Name	Description
PROCEDURE	Greater Occipital Nerve Block	An enjection to paralyze the occipital nerve.
DRUG	Topiramate	An antiepileptic agent used for migraine prophylaxis.
DRUG	Flunarizine	A calcium overload blocker agent used for migraine prophylaxis.

Timeline

• Start date: 2019-03-01
• Primary completion: 2019-03-31
• Completion: 2019-03-31
• First posted: 2018-10-19
• Last updated: 2020-01-21
• Results posted: 2020-01-21

Locations

1 site across 1 country: Turkey (Türkiye)