Clinical Trials Directory

Trials / Completed

CompletedNCT03708055

Weight Bearing Exercise in Preventing Frailty in Stage I-IIIA Breast Cancer Survivors

Prevention of Frailty in Breast Cancer Survivors: A Pilot Study

Status
Completed
Phase
N/A
Study type
Interventional
Enrollment
27 (actual)
Sponsor
University of Arizona · Academic / Other
Sex
All
Age
37 Years – 65 Years
Healthy volunteers
Not accepted

Summary

This trial studies how well weight bearing exercise works in preventing frailty in stage I-IIIA breast cancer survivors. Weight bearing exercise, including muscle-strengthening, aerobic, flexibility, and balance exercises, can decrease fat and increase muscle, which may lead to reduced frailty.

Detailed description

PRIMARY OBJECTIVES: I. Demonstrate reproducibility of forearm muscle activation and subcutaneous fat measures in a healthy convenience sample/population (N= 10). II. Demonstrate that measures of muscle activation and signal attenuation by subcutaneous fat mass can be conducted in a systematic and reproducible fashion in breast cancer survivors prior to and following weight bearing exercise training. III. In a cross sectional analysis, describe the level of lean muscle mass, muscle activation, strength, insulin resistance, inflammatory cytokines and growth factors, and inter-individual variability in breast cancer survivors prior to training. IV. Describe the level of lean muscle mass, muscle activation, strength, insulin resistance, inflammatory cytokines (such as IL-6, CRP and others), and growth factors (such as myostatin, IGF-1, IGFBP-3 and others) in breast cancer survivors following weight bearing exercise training. V. Evaluate the influence of genetic variability on response to prescribed training in breast cancer survivors. OUTLINE: Participants undergo a weight bearing exercise program in a group 2 days a week and at home 5 days a week for 8 weeks.

Conditions

Interventions

TypeNameDescription
BEHAVIORALExercise InterventionUndergo weight bearing exercise program

Timeline

Start date
2008-07-24
Primary completion
2017-04-04
Completion
2017-04-04
First posted
2018-10-16
Last updated
2018-10-23

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT03708055. Inclusion in this directory is not an endorsement.