NCT03705559

Opioid and Cannabinoid Interactions

Interactions of Marijuana and Opioids: Pharmacodynamic Effects

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Shanna Babalonis, PhD · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study will examine the effects of doses of marijuana/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) to determine the interaction effects of these compounds.

Conditions

• Marijuana Usage
• Opioid Use

Interventions

Type	Name	Description
DRUG	Vaporized Marijuana	Active Marijuana administered through vaporizer
DRUG	Opioid Agonist	Active Opioid Agonist administered intranasally
DRUG	Placebo	Experimental, non-therapeutic administration of inactive opioid or marijuana dose(s)

Timeline

• Start date: 2019-06-21
• Primary completion: 2024-02-15
• Completion: 2024-02-15
• First posted: 2018-10-15
• Last updated: 2025-04-10
• Results posted: 2025-04-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study