NCT03704987

Skeletal Health of Klinefelter Patients

Skeletal Health of Klinefelter Patients is Not so Bad

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 247 (actual)
• Sponsor: TC Erciyes University · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study compared the bone health of KS patients who were actively monitored in our clinic by dual-energy X-ray absorptiometry (DXA) with that of a control group of healthy volunteers.

Detailed description

Klinefelter syndrome (KS) is the most common chromosome number abnormality of men, occurring in 1/500 to 1/1000 live births . It was first described in 1942 as an endocrine disorder characterised by small, hard testicles androgen deficiency, gynaecomastia and increased follicle stimulating hormone (FSH). Osteoporosis is a progressive bone remodelling disorder in which bone loss exceeds bone formation. The resulting micro-architectural defects and bone fragility are associated with increased fracture risk and mortality. In KS, testosterone deficiency is associated with decreased bone mass and low bone mineral density (BMD) , and a positive correlation of total serum testosterone and BMD has been reported . There are some exceptions ; however, most studies have reported that KS increases the risk of osteopenia and osteoporosis compared with age-matched control groups.

Conditions

• Osteoporosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	dual-energy X-ray absorptiometry	dual-energy X-ray absorptiometry

Timeline

• Start date: 2015-01-01
• Primary completion: 2017-07-31
• Completion: 2017-08-31
• First posted: 2018-10-15
• Last updated: 2018-10-15

Locations

1 site across 1 country: Turkey (Türkiye)