NCT03694132

Brain Excitability and Connectivity in Sensory-motor Pathways in ALS

Evaluation and Characterization of Infraclinical Sensory Deficits in Amyotrophic Lateral Sclerosis by Brain Imaging and Electrophysiology

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology. The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).

Detailed description

Somatosensory evoked potentials (SEPs) produced by ulnar nerve electrical stimulation will be collected with combined MEG and EGG. Functional MRI will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of ADM tendon. Brain diffusion MRI will be performed. Anatomical MRI will be done for source location. Brain resting state activity will be recorded with MEG/EEG and fMRI.

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

Type	Name	Description
DEVICE	functional MRI	conditioning brain activity with peripheral stimulations
DEVICE	structural MRI	diffusion MRI and tractography for evaluating the brain structures
DEVICE	EEG/MEG	conditioning brain activity with peripheral stimulations

Timeline

• Start date: 2018-11-26
• Primary completion: 2019-12-31
• Completion: 2021-03-31
• First posted: 2018-10-03
• Last updated: 2025-11-18

Locations

1 site across 1 country: France