NCT03691688

The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA）

The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA): A Prospective Cohort Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The deleterious effects of hyperuricemia (HUA) on cardiovascular disease (CVD) were well established. Aspirin is the most commonly prescribed antiplatelet agent for primary or secondary prophylaxis of CVD. Only a few short-term studies in the elderly suggested low-dose aspirin, e.g., 75-100 mg/day, increases serum urate by reducing urinary uric acid excretion. However, monitoring of renal function is currently not recommended. Little is known about the long-term effect of low dose aspirin on uric acid. The principal aim of this prospective cohort study therefore is to evaluate the renal effects of long-term aspirin (100 mg/d) administration in Chinese patients with coronary artery disease or other CVDs.

Conditions

• Coronary Artery Disease
• Hyperuricemia

Interventions

Type	Name	Description
DRUG	Aspirin 100 mg	Aspirin 100mg will be prescribed for antiplatelet therapy at the physician's discretion
DRUG	Clopidogrel 75mg	Clopidogrel will be prescribed for antiplatelet therapy in case of aspirin intolerance at the physician's discretion

Timeline

• Start date: 2018-12-01
• Primary completion: 2021-11-01
• Completion: 2022-03-01
• First posted: 2018-10-02
• Last updated: 2018-11-29

Locations

1 site across 1 country: China