NCT03683654

Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Mining the Urinary and Serum Metabolome for Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 494 (actual)
• Sponsor: International Agency for Research on Cancer · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.

Detailed description

Subjects participating in the study are characterized by the availability of one 24-hr urine sample, blood serum, 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ) data. The main objectives of the proposal are: 1. To collect a set of high-quality metabolomic data containing rich information on the food-derived metabolome. 2. To mine this data in different Metabolome-Wide Association Studies in order to identify food-derived metabolites discriminating consumers and non-consumers of various foods, nutrients and dietary patterns. 3. To identify the food-derived metabolites characteristic of the consumption of the different foods/nutrients and dietary patterns.

Conditions

• Dietary Exposure

Interventions

Type	Name	Description
OTHER	Identify Biomarkers of Dietary Intake in Healthy Subjects	Observational study. No intervention.

Timeline

• Start date: 2012-04-26
• Primary completion: 2013-02-23
• Completion: 2013-02-23
• First posted: 2018-09-25
• Last updated: 2018-10-10