NCT03676166

Pharmacokinetic and Pharmacodynamic Effects of Smoked and Vaporized Cannabis

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of smoked and vaporized cannabis. Careful analysis of different cannabis administration methods on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. In the present study the investigators evaluated the detection of cannabinoids in whole blood, oral fluid, and urine, as well as the acute pharmacodynamics associated with smoked and vaporized cannabis among individuals who were not regular cannabis users. The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of smoked and vaporized cannabis administration and can inform policies regarding clinical, workplace and roadside drug testing programs.

Conditions

• Cannabis

Interventions

Type	Name	Description
DRUG	Cannabis	Inhaled cannabis

Timeline

• Start date: 2016-06-16
• Primary completion: 2017-01-17
• Completion: 2017-01-17
• First posted: 2018-09-18
• Last updated: 2019-09-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study