NCT03672331

My Personalized Breast Screening

International Randomized Study Comparing Personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 53,142 (actual)
• Sponsor: UNICANCER · Academic / Other
• Sex: Female
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

MyPeBS is an international randomized, open-label, multicentric, study assessing the effectiveness of a risk-based breast cancer screening strategy (using clinical risk scores and polymorphisms) compared to standard screening (according to the current national guidelines in each participating country) in detecting stage 2 or higher breast cancers. Women will be differentially screened for 4 years and then, after an end-of-study mammogram, they will return to the routine screening practice. The main study endpoint will be measured at the end of the four years of intervention. Furthermore, follow up data will be collected for 15 years from study entry for evaluation of long-term cumulative breast cancer incidence and breast cancer-specific survival

Conditions

• Breast Screening

Interventions

Type	Name	Description
OTHER	Mammogram	Every 1-4 years according to the national/regional guidelines or personalised schedule according to risk assessment
OTHER	Ultrasound	As required according to the national/regional guidelines or personalised schedule according to risk assessment
OTHER	MRI	As required according to the national/regional guidelines or personalised schedule according to risk assessment
OTHER	Tomosynthesis	As required according to the national/regional guidelines or personalised schedule according to risk assessment

Timeline

• Start date: 2019-07-18
• Primary completion: 2027-08-31
• Completion: 2027-12-31
• First posted: 2018-09-14
• Last updated: 2025-09-18

Locations

6 sites across 6 countries: Belgium, France, Israel, Italy, Spain, United Kingdom