NCT03667807

TMS-induced Plasticity Improving Cognitive Control in OCD

Transcranial Magnetic Stimulation (TMS)-Induced Plasticity Improving Cognitive Control in Obsessive-compulsive Disorder (OCD)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Repetitive transcranial magnetic stimulation (rTMS) has been shown in several previous clinical trials to be an effective treatment for obsessive-compulsive disorder (OCD). However, the neural working mechanisms of rTMS in OCD are unknown, and the optimal stimulation sites have not yet been established. Our study aims to compare the clinical and neurobiological effects of three different rTMS stimulation protocols in OCD patients. 8 weeks of rTMS therapy will be delivered in combination with cognitive behavioural therapy. Multimodal neuroimaging will be carried out before and after treatment in order to demonstrate the neurobiological effects of the therapy.

Conditions

• Obsessive-Compulsive Disorder

Interventions

Type	Name	Description
DEVICE	Repetitive transcranial magnetic stimulation	Non invasive brain stimulation

Timeline

• Start date: 2019-05-08
• Primary completion: 2022-10-01
• Completion: 2023-07-01
• First posted: 2018-09-12
• Last updated: 2023-05-11

Locations

1 site across 1 country: Netherlands