Trials / Completed
CompletedNCT03663140
Neurogenic Inflammation in Peri-implant and Periodontal Diseases
Neurogenic Inflammatory Response in Peri-implant and Periodontal Diseases Assessed by Biochemical Analysis of the Neuropeptides in Gingival Crevicular Fluid.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 39 (actual)
- Sponsor
- Ondokuz Mayıs University · Academic / Other
- Sex
- Male
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the impact of neuropeptide levels are not clearly defined in healthy and diseased peri-implant tissues.ın order to evaluate the situation, thirty-nine implants that have been loaded over the past 12 months and their symmetrically matching teeth were evaluated using a split-mouth study design. Clinical periodontal examinations included the Silness-Löe plaque index, Löe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level parameters were determined. Gingival crevicular fluid (GCF)/Periimplant sulcular fluid (PISF) samples were collected, and the levels of the neuropeptides were determined by enzyme-linked immunosorbent assay. Correlations between GCF/PISF neuropeptide levels and the clinical examination parameters were evaluated in the peri-implant/periodontal soft tissues.
Conditions
- Neurogenic Inflammation
- Periimplant Diseases
- Periodontal Diseases
- Gingival Crevicular Fluid
- Periimplant Sulcular Fluid
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | gingival crevicular fluid (GCF) and peri-implant sulcular fluid(PISF) collection | GCF/PISF samples were collected using periopaper strips. Prior to sample collection, each site was gently air-dried, all supragingival plaque was removed, and the area was carefully isolated to prevent samples from being contaminated by saliva. |
Timeline
- Start date
- 2011-01-01
- Primary completion
- 2013-09-15
- Completion
- 2013-12-30
- First posted
- 2018-09-10
- Last updated
- 2018-09-13
Source: ClinicalTrials.gov record NCT03663140. Inclusion in this directory is not an endorsement.