NCT03656029

Dose-response of Cannabis and Driving

Dose-dependent Effects of Smoked Cannabis on Simulated Driving Performance

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Centre for Addiction and Mental Health · Academic / Other
• Sex: All
• Age: 19 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Epidemiological studies have established a link between collisions while driving and cannabis use. With the changing legal landscape around cannabis, there is much interest in determining per se limits of cannabis while driving. The present study will evaluate driving on a driving simulator after smoking placebo or cannabis with 3 different levels of THC. THC is the active component in cannabis and blood, urine and oral fluid levels of THC will be correlated with driving impairment.

Detailed description

Participants will attend the laboratory for 4 separate sessions, separated by about a week. In each session, participants will receive one of 3 doses of smoked cannabis or a placebo. Participants will not know which dose they are receiving. Participants will complete questionnaires, do cognitive tests and drive on a driving simulator before and after smoking the cannabis or placebo cigarette. Blood, urine and oral fluid will be collected throughout the 7-8 hour session to determine levels of THC and its metabolites. These values will be correlated with measures of driving impairment.

Conditions

• Driving Impaired
• Cognitive Impairment
• Abuse Cannabis

Interventions

Type	Name	Description
DRUG	Cannabis	Participants will smoke as much of the cigarette as they wish
DRUG	Placebo	Participants will smoke a placebo cigarette

Timeline

• Start date: 2021-06-04
• Primary completion: 2022-06-14
• Completion: 2022-06-14
• First posted: 2018-09-04
• Last updated: 2022-10-07

Locations

1 site across 1 country: Canada