NCT03655249

Effects of AD on VI in Patients With CF

Effects of Autogenic Drainage on Ventilation Inhomogeneity in Patients With Cystic Fibrosis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 6 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome

Detailed description

This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis. Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.

Conditions

• Cystic Fibrosis

Interventions

Type	Name	Description
OTHER	Autogenic drainage	Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity.
DRUG	Aerosoltherapy	Aerosolized drugs are individualized for each participants, in line with current standardized practice in our hospital. Those drugs will not be modified for the purpose of this study.

Timeline

• Start date: 2018-08-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2018-08-31
• Last updated: 2024-07-01

Locations

1 site across 1 country: Belgium