NCT03647345

Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Mild Cognitive Impairment

Investigation for Individualized Noninvasive Neuromodulation in Mild Cognitive Impairment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of mild cognitive impairment (MCI) patients' cognitive function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in MCI patients. In this study, simultaneous stimulation using both facilitatory rTMS (10Hz) and anodal or cathodal tDCS (dual-mode stimulation) over bilateral dorsolateral prefrontal cortices (DLPFCs) was investigated to compare its modulatory effects with single facilitatory rTMS stimulation in mild cognitive impairment patients.

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC	10Hz rTMS over the left DLPFC and anodal tDCS over the right DLPFC are simultaneously stimulated.
DEVICE	High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC	10Hz rTMS over the left DLPFC and cathodal tDCS over the right DLPFC are simultaneously stimulated.
DEVICE	High-frequency rTMS on left DLPFC+sham tDCS on right DLPFC	10Hz rTMS over the left DLPFC and sham tDCS (no stimulation) over the right DLPFC are simultaneously stimulated.

Timeline

• Start date: 2015-04-26
• Primary completion: 2018-07-05
• Completion: 2018-07-05
• First posted: 2018-08-27
• Last updated: 2019-09-20

Locations

1 site across 1 country: South Korea