NCT03644420

Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis

Association Between Preoperative Clinical Evaluation, Radiological Classifications and Histopathology in Patients With Knee Osteoarthritis Receiving a Prosthesis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 22 (actual)
• Sponsor: Lille Catholic University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically. The area of greatest change is at the subchondral/cartilage bone junction. Investigators will determine the association between preoperative clinical evaluation (IKDC and Womac scores), radiological classifications and histopathology. In addition, the role of inflammation in the pathogenesis of osteoarthritis is being given major interest, and inflammation is closely linked with vascularization. It was recently demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in animals. These changes appeared before cartilage lesions were visible and were correlated with osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone vascularization in non-invasive conditions in humans might help better understanding osteoarthritis pathophysiology and finding new biomarkers. Investigators hypothesized that, as in animals, DCE-MRI has the ability to identify subchondral bone marrow vascularization changes in human osteoarthritis.

Conditions

• Osteoarthritis, Knee
• Perfusion
• Bone Marrow
• Magnetic Resonance Imaging

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Clinical evaluation	Functional scores for the pathological joint will be determined
DIAGNOSTIC_TEST	Radiology
DIAGNOSTIC_TEST	Dynamic contrast-enhanced magnetic resonance imaging	Patients will be examined using a 3T MR scanner (MR 750W, General Electrics, Milwaukee, WI) with a dedicated knee coil. Subchondral bone marrow vascularization in medial and lateral femorotibial compartments will be assessed with DCE-MRI and lesions will be graded on MR images.
DIAGNOSTIC_TEST	Evaluation of histological status	Upper tibial resection pieces will be collected and the vascularization will be determined according to the OARSI score

Timeline

• Start date: 2013-05-01
• Primary completion: 2016-04-01
• Completion: 2016-12-01
• First posted: 2018-08-23
• Last updated: 2018-08-23