NCT03627611

Identification of Non-responders to Levothyroxine Therapy

A Randomized Crossover Study, Examining Differential Effects of Levothyroxine and Liothyronine

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level

Detailed description

15-20% of the patients with hypothyroidism remain symptomatic, despite adequate thyroxine substitution. Endocrinologists are split in their opinion on combination therapy with T4 and T3 on patients with poorly regulated hypothyroidism. There are no objective means, by which to identify individuals who would benefit from combination therapy. The purpose of this study is to assess differential effects of T4 and T3 on body temperature, metabolism, muscle strength and brain function. The main aim is to try to identify biomarkers reflecting different effects of T4 and T3 on cell and tissue level.

Conditions

• Hypothyroidism
• Biomarkers
• Endocrine System Diseases

Interventions

Type	Name	Description
DRUG	Levothyroxin	3 months
DRUG	Liothyronine	3 months

Timeline

• Start date: 2018-08-14
• Primary completion: 2020-06-22
• Completion: 2020-06-22
• First posted: 2018-08-13
• Last updated: 2021-03-17

Locations

1 site across 1 country: Norway