NCT03616379

Stress Response in Opioid Use Disorder

Behavioral Strategies to Reduce Stress Reactivity in Opioid Use Disorder

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: Mclean Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Opioid use disorder is a major public health problem. Although there are effective treatments for this disorder, many people still relapse and thus there is a need for new treatments to improve outcomes. People who have a strong emotional and physical response to stress are at a higher risk of relapse. The goal of this project is to test the effect of strategies to reduce response to stress in people diagnosed with opioid use disorder. Men and women diagnosed with opioid use disorder will be recruited for a one-session study. Participants will be randomly assigned to one of three brief instructional conditions followed by a brief laboratory stress test. Investigators hypothesize that, compared to education about stress, brief strategies to help people cope with negative emotions will reduce responses to stress and increase tolerance of stress. If this hypothesis is supported, it will inform the development of new treatments to improve outcome in opioid use disorder.

Conditions

• Opioid-use Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Psychoeducational Control	The Psychoeducational Control condition will consist of a brief script describing the body's response to stress and will not discuss cognition or the role of interpretation or affect labeling during stress.
BEHAVIORAL	Affect Regulation	In the Affect Regulation Condition, participants will be provided instructions for how to reappraise negative thoughts in the context of stress by developing statements consistent with more benign interpretations of stress (e.g., This won't last forever.).
BEHAVIORAL	Affect Labelling	In the Affect Labeling Condition, participants will be provided with instructions for how to verbalize their emotional response during the stressor.

Timeline

• Start date: 2019-05-31
• Primary completion: 2022-08-31
• Completion: 2022-08-31
• First posted: 2018-08-06
• Last updated: 2024-04-01
• Results posted: 2024-04-01

Locations

1 site across 1 country: United States