NCT03610893

Dexamethasone Versus Dexmedetomidine as Adjuvants for Nerve Blocks

A Randomized Comparison Between Perineural Dexamethasone and Perineural Dexmedetomidine as Adjuvants for Ultrasound-Guided Infraclavicular Blocks

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: University of Chile · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

When used as perineural (PN) adjuvants to local anesthetics (LAs), dexamethasone (DX) and dexmedetomidine (DXD) have been well documented to prolong the duration of peripheral nerve blocks. These drugs have important differences in terms of cost and safety profiles. This randomized controlled trial (RCT) will compare PN DX and PN DXD for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Since analgesic and sensory duration can be influenced by factors different to block, motor block duration is the main outcome. The protocol is designed as an equivalency trial and hypothesize that both drugs result in similar durations. The equivalency margin is set at 3 hrs.

Conditions

• Pain, Postoperative
• Pain, Acute
• Upper Extremity Injury

Interventions

Type	Name	Description
DRUG	Dexamethasone	Dexamethasone as perineural local anesthetic adjuvant
DRUG	Dexmedetomidine	Dexmedetomidine as perineural local anesthetic adjuvant

Timeline

• Start date: 2018-08-16
• Primary completion: 2019-04-30
• Completion: 2019-04-30
• First posted: 2018-08-01
• Last updated: 2019-05-01

Locations

1 site across 1 country: Chile