NCT03606421

CBF and NCF Changes With Brain Radiation

Use of Novel MRI Techniques Before and After Brain Radiotherapy With Parallel Assessments of Neurocognitive Function

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 110 (estimated)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will be a dual-arm prospective longitudinal cohort study for patients with brain metastases, at least one of which is appropriate for radiotherapy, to explore brain and cognitive changes following SRS or WBRT and evaluate the feasibility of a novel MRI protocol to identify potential radiological biomarkers of NCF decline. Patients diagnosed with brain mets will be assigned to either Arm A or Arm B, depending on their treatment plan. Patients in Arm A will be treated with SRS. Patients in Arm B will be treated with WBRT. Patients' neurocognitive function will be assessed before their radiation treatment and followed up for 2 years post treatment.

Conditions

• Neurocognitive Dysfunction
• Brain Metastases

Interventions

Type	Name	Description
RADIATION	SRS and neurocognitive assessments	Patients will be assessed for cerebral blood flow and their neurocognitive function based on a series of neurocognitive tests and questionnaires.
RADIATION	WBRT and neurocognitive assessments	Patients will be assessed for cerebral blood flow and their neurocognitive function based on a series of neurocognitive tests and questionnaires.

Timeline

• Start date: 2018-10-01
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2018-07-30
• Last updated: 2026-03-06

Locations

1 site across 1 country: Canada