NCT03598075

Amylin and CGRP Head to Head Provocation in Migraine Without Aura Patients

Amylin and CGRP Migraine Provocation in Migraine Without Aura Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Amylin and calcitonin gene related peptide (CGRP) are related to the same peptide family. Both share 16 out of 37 amino acids and can activate each others receptor. CGRP is implicated in migraine pathophysiology but the role of Amylin and its receptor in migraine is not fully clarified.

Detailed description

Amylin is a peptide hormone that binds to a G-protein coupled receptor (GPCR). amylin was originally found in the pancreas (Beta Cell of Islets of Langerhans) but also shown to be present in the trigeminal ganglion, hind horn ganglia and perivascular nerve fibers. Amylin has many similarities with CGRP. Amylin and CGRP share 16 out 37 amino acids. Both peptides can activate the amylin 1 subtype (AMY1)receptor with high affinity and reported to have more similar physiological and pharmacological effects. In addition, both peptides increase the intracellular concentration of cyclic AMP (cAMP) which has a central role in migraine pathophysiology. The aim of the study is pin point the role of amylin and amylin receptor compare to CGRP in migraine pathophysiology.

Conditions

• Migraine Without Aura

Interventions

Type	Name	Description
OTHER	Amylin (Pramlintide)	Pramlintide is a amylin analog. It will be given intravenously at the rate of 120 micrograms over 20 minutes .
OTHER	CGRP	CGRP It will be given intravenously at the rate of 30 microgram over 20 minutes.

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-09-30
• Completion: 2019-12-31
• First posted: 2018-07-26
• Last updated: 2020-06-25

Locations

1 site across 1 country: Denmark