Trials / Completed
CompletedNCT03585894
The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 34 (actual)
- Sponsor
- Danish Headache Center · Academic / Other
- Sex
- All
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and pre-posttreated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on healthy volunteers.
Detailed description
The purpose of this research project is to investigate the importance of blood vessel (vasodilatation), vessel wall inflammation and blood flow in arteries of headaches triggered by PACAP38 and for headache treated with sumatriptan (migraine medicine) and ketorolac (NSAID). In addition, we will investigate headache-related changes in the brain's network connectivity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Sumatriptan | Receive intravenous infusion of sumatriptan |
| OTHER | Ketorolac | Receive intravenous infusion of ketorolac |
Timeline
- Start date
- 2018-08-01
- Primary completion
- 2019-08-01
- Completion
- 2019-11-25
- First posted
- 2018-07-13
- Last updated
- 2020-01-02
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT03585894. Inclusion in this directory is not an endorsement.