NCT03583112

Investigation of the Changes of Brain Structure and Function in Premature Ejaculation Patients and the Effects of Dapoxetine on Central Neural Activity in Premature Ejaculation Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Xidian University · Academic / Other
• Sex: Male
• Age: 18 Years – 64 Years
• Healthy volunteers: Accepted

Summary

Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear. In recent years, dapoxetine, a highly potent serotonin-transporter inhibitor, has been used for treating premature ejaculation. However, the underlying mechanism of dapoxetine was unknown. Recently, with widespread use of neuroimaging techniques, like positron emission tomography and magnetic resonance imaging (MRI) in basic science, researchers can acquire human data on cerebral base of human sexual behavior, not only in normal subjects but also in patients with sexual dysfunction. Therefore, in order to further understand the biological mechanism of LPE and the brain targets of dapoxetine, the present study would investigate the brain changes of LPE and the effect of dapoxetine on brain activation by using MRI technology.

Conditions

• Premature Ejaculation

Interventions

Type	Name	Description
DRUG	Dapoxetine Hydrochloride Tablet	oral one dapoxetine hydrochloride tablet before MRI scan
DRUG	Placebo Tablet	oral one placebo tablet before MRI scan.

Timeline

• Start date: 2018-07-10
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2018-07-11
• Last updated: 2018-08-24

Locations

1 site across 1 country: China