NCT03577808

Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer

Validation of Organoids Potential Use as a Companion Diagnostic in Predicting Neoadjuvant Chemoradiation Sensitivity in Locally Advanced Rectal Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Zhen Zhang · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: —

Summary

Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose organoids to irradiation and the same chemotherapy drugs. The sensitivity of irradiation and chemotherapy drugs will be tested in the organoids model. Here, the investigators will launch the observational clinical trial to validate whether the organoids could predict the clinical outcome in locally advanced rectal cancer patients underwent neoadjuvant chemoradiation.

Conditions

• Organoids
• Rectal Cancer
• Chemoradiation

Interventions

Type	Name	Description
OTHER	Biopsy	Patients with locally advanced rectal cancer will receive biopsy of the primary tumor before neoadjuvant chemoradiation.

Timeline

• Start date: 2018-08-17
• Primary completion: 2020-08-01
• Completion: 2020-11-01
• First posted: 2018-07-05
• Last updated: 2018-08-20

Locations

1 site across 1 country: China