NCT03572088

Terlipressin Infusion During Whipple Procedure: Effect on Blood Loss and Transfusion Needs

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The present study aims to look at the effect of terlipressin infusion on blood loss and blood transfusion needs during Whipple procedure

Conditions

• Terlipressin
• Blood Loss

Interventions

Type	Name	Description
DRUG	Terlipressin	Terlipressin is a synthetic vasopressin analogue with relative specificity for the splanchnic circulation(Terlipressin was started at the beginning of surgery as an initial bolus dose of 1 mg over 30 mints(1 mg/50 ml normal saline at a rate of 100 ml/h) followed by a continuous infusion of 2 μg/kg/h(1 mg/50 ml at a rate equal to wt/10 ml per hour) and weaned in the postoperative period over 4 hours.)
DRUG	normal saline	Patients received 50 ml normal saline at a rate of 100 ml/h followed by a continuous infusion of 50 ml at a rate equal to wt/10 ml per hour and weaned in the postoperative period over 4 hours.

Timeline

• Start date: 2016-05-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2018-06-28
• Last updated: 2023-05-22