Trials / Unknown
UnknownNCT03568032
Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma
The Clinical Study of Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma Treated by IMRT
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 248 (estimated)
- Sponsor
- Fudan University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke. Currently, little is known about the incidence of radiation-associated carotid vasculopahty in the context of intensity-modulated radiation therapy (IMRT). The aim of this study is to determine whether IMRT will increase the incidence of carotid vasculopathy in patients with nasopharyngeal carcinoma (NPC).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Measurement of intima media thickness of carotid artery | IMT measurements were performed using ultrasound machine in the pre-radiation and the post-radiation group. IMT was assessed at the common carotid artery (CCA) and the internal carotid artery (ICA) of both the left and right side. |
| DIAGNOSTIC_TEST | Detection and measurement of carotid plaques | Detection and measurement of plaques within internal carotid artery and common carotid artery by ultrasound |
| DIAGNOSTIC_TEST | Carotid Color Flow Duplex Testing | Velocity measurement of carotid artery to determine carotid stenosis |
| DIAGNOSTIC_TEST | Montreal Cognitive Assessment | Cognitive assessment |
| OTHER | Medical history of cardiovascular risk factors and cardiovascular diseases | Cardiovascular risk factors include smoking, alcohol consumption, hypertension, diabetes mellitus, hypercholesterolemia, obesity. Cardiovascular diseases include ischemic stroke, ischemic coronary heart disease, TIA, etc. |
Timeline
- Start date
- 2018-07-01
- Primary completion
- 2019-05-01
- Completion
- 2019-06-30
- First posted
- 2018-06-26
- Last updated
- 2018-06-26
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03568032. Inclusion in this directory is not an endorsement.