NCT03563521

Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma

Serum Cytokine Profiles of Severe Asthma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 95 (actual)
• Sponsor: TC Erciyes University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or chronic rhinosinusitis and/or nasal polyposis status.

Detailed description

A prospective observational study of 90 adults diagnosed with severe asthma and on regular follow-up and 15 control subjects will be investigated. Stable (controlled or partly-controlled) status (of all) and exacerbated-status (if any) serum cytokine levels \[IL-4, IL-5, IL-10, IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP), IL-17A, periostin) will be evaluated. Also nasopharyngeal brush samples will be obtained for respiratory tract panel work-up with PCR in exacerbated patients. Effect of viral infections' on cytokine response in different inflammatory phenotypes will be evaluated.

Conditions

• Asthma Persistent
• Asthma, Allergic
• Eosinophilic Asthma
• Chronic Rhinosinusitis (Diagnosis)

Timeline

• Start date: 2017-11-27
• Primary completion: 2019-02-01
• Completion: 2019-06-28
• First posted: 2018-06-20
• Last updated: 2019-07-18

Locations

1 site across 1 country: Turkey (Türkiye)