| Recruiting | Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis NCT05427695 | University of Illinois at Chicago | Phase 2 |
| Recruiting | Effect of Photobiostimulation Versus Pulsed Electromagnetic Field on Quality of Life in Adults With Chronic Rh NCT06986629 | Cairo University | N/A |
| Active Not Recruiting | The Sinonasal Microbiome NCT06822725 | University of Chicago | — |
| Not Yet Recruiting | Comparative Analysis of Silastic Stenting in Sinus Surgery NCT06502197 | University of British Columbia | N/A |
| Completed | Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis NCT07198607 | Liaquat University of Medical & Health Sciences | N/A |
| Recruiting | The Role of IL5 in Epithelial Cell Integrity NCT05895929 | Johns Hopkins University | EARLY_Phase 1 |
| Recruiting | The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhino NCT05882903 | Oticara Australia PTY LTD | Phase 2 |
| Completed | Propel Drug-Eluting Sinus Stent Family Open Cohort NCT05925985 | Medtronic | — |
| Active Not Recruiting | Viral and Epigenetic Influences in CRSwNP NCT05857228 | Centre hospitalier de l'Université de Montréal (CHUM) | — |
| Recruiting | Sinus Disease in Young Children With Cystic Fibrosis NCT06191640 | University of California, Los Angeles | — |
| Unknown | A Prospective Single-center Cohort Study of Surgical Treatment of Chronic Rhinosinusitis NCT06010316 | Beijing Tongren Hospital | — |
| Enrolling By Invitation | Xylitol vs Saline Nasal Irrigations in CF-CRS NCT05531630 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | Role of Nanoemulsified Sesame Oil in Post-operative Care After Endoscopic Sinus Surgery NCT06437717 | Mansoura University | N/A |
| Unknown | Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) NCT05400616 | The University of Queensland | N/A |
| Unknown | Adherence in Global Airways NCT05553951 | Christiane Haase | N/A |
| Terminated | Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery NCT05287217 | University of Illinois at Chicago | N/A |
| Completed | Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) NCT05295459 | Lyra Therapeutics | Phase 3 |
| Terminated | Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream NCT05220293 | Oticara Australia PTY LTD | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults NCT05219968 | Lyra Therapeutics | Phase 3 |
| Withdrawn | Impact of Chronic Rhinosinusitis on the Index of Ciliary Beat Efficiency Using Fluorescent Nanosticks: (R-IMPA NCT04191590 | Centre Hospitalier Intercommunal Creteil | N/A |
| Completed | LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) NCT05035654 | Lyra Therapeutics | Phase 2 |
| Recruiting | Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Pat NCT05009758 | Medical University of Vienna | N/A |
| Unknown | Bacteriophage Therapy for Difficult-to-treat Infections: the Implementation of a Multidisciplinary Phage Task NCT06368388 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | A Clinical Evaluation of PROPEL® Contour Sinus Implant NCT04858802 | Intersect ENT | N/A |
| Completed | Subcutaneously CM310/Placebo in Patients With Chronic Rhinosinusitis With Nasal Polyposis (CROWNS-1) NCT04805398 | Keymed Biosciences Co.Ltd | Phase 2 |
| Withdrawn | Efficacy of Budesonide Via Delayed Release vs Immediate Release NCT04476628 | St. Paul's Hospital, Canada | EARLY_Phase 1 |
| Recruiting | Real-Life Chronic Rhinosinusitis Outcome Registry NCT04670172 | Change Accelerator in Respiratory Care | — |
| Recruiting | The Nasal Microbiome and Its Importance in Disease NCT05061329 | University of Aarhus | — |
| Completed | Tissue Immune Interaction in Nasal Polyposis NCT04628442 | University of California, San Francisco | — |
| Unknown | Alsaleh-Javer Endoscopic Sinus Score (AJESS) System NCT04514120 | St. Paul's Hospital, Canada | N/A |
| Withdrawn | Hypertonic Versus Isotonic Saline Irrigations for Chronic Rhinosinusitis NCT04242368 | Stanford University | Phase 2 / Phase 3 |
| Recruiting | Impact of Sinus Surgery on Individuals With Cystic Fibrosis NCT04469439 | University of California, Los Angeles | — |
| Completed | Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis NCT04572516 | Benha University | Phase 3 |
| Unknown | Povidone-Iodine Rinses as an Adjuvant Therapy Post-Operatively NCT04278950 | St. Paul's Hospital, Canada | N/A |
| Active Not Recruiting | Functional Endoscopic Sinus Surgery Study NCT03970655 | University of Florida | Phase 1 / Phase 2 |
| Unknown | NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP NCT03963648 | Christian von Buchwald | N/A |
| Withdrawn | Effect of Topical Sinonasal Antibiotics NCT03935828 | United States Naval Medical Center, San Diego | Phase 2 |
| Completed | LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study) NCT04041609 | Lyra Therapeutics | Phase 2 |
| Recruiting | Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis NCT03439865 | University of Alabama at Birmingham | EARLY_Phase 1 |
| Completed | Aggravated Airway Inflammation: Research on Genomics and Optimal Medical Care (AirGOs-medical) NCT03825757 | Sanna Salmi | N/A |
| Completed | Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation NCT03893227 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages NCT03979209 | Rush University Medical Center | Phase 1 |
| Completed | The Influence of Blood Pressure Upon the Clarity of Surgical Field in Endonasal Surgery NCT03815435 | University Hospital Ostrava | N/A |
| Completed | Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis NCT03705793 | Washington University School of Medicine | Phase 4 |
| Completed | Topical Antibiotics in Chronic Rhinosinusitis NCT03673956 | Mayo Clinic | Phase 1 / Phase 2 |
| Unknown | Use of Budesonide Diluted to Maximum Clinical Treatment of Patients With Chronic Rhinosinusitis With Polyoposi NCT05541419 | Universidade Estadual de Londrina | N/A |
| Unknown | Debridement and Functional Endoscopic Sinus Surgery NCT04093193 | St. Paul's Hospital, Canada | N/A |
| Completed | A Clinical Evaluation of the Intersect ENT Sinus Device (ASCEND) NCT03599271 | Intersect ENT | — |
| Completed | Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation NCT03427502 | Lumbini Medical College | N/A |
| Unknown | Study of Probiotic Potential of Lactobacillus Strains in the Upper Respiratory Tract After Nasal Spray Applica NCT03587545 | University Hospital, Antwerp | N/A |
| Completed | The Effect of Enhanced Recovery After Surgery in Endoscopic Sinus Surgery NCT04048070 | Beijing Tongren Hospital | N/A |
| Withdrawn | Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients NCT03303677 | University of Florida | Phase 3 |
| Withdrawn | Silver Nanoparticle Investigation for Treating Chronic Sinusitis NCT03243201 | Washington University School of Medicine | Phase 1 |
| Completed | Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma NCT03563521 | TC Erciyes University | — |
| Withdrawn | Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab NCT03369574 | University of Rochester | — |
| Terminated | Steroid Delivery to the Frontal Sinus Opening With a Bioabsorbable Implant vs. a Bioabsorbable Nasal Dressing NCT03188822 | University of Rochester | N/A |
| Completed | Betadine Rinses for Chronic Rhinosinusitis Prospective Cohort Study NCT04097613 | St. Paul's Hospital, Canada | EARLY_Phase 1 |
| Completed | Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis NCT03450083 | Johns Hopkins University | Phase 2 |
| Completed | Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) NCT03122795 | Region Skane | N/A |
| Completed | Effect of Patient Education Videos on Perioperative Anxiety in Patients Undergoing Endoscopic Sinus Surgery NCT04595461 | University of British Columbia | N/A |
| Active Not Recruiting | The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammator NCT04171167 | Tampere University Hospital | N/A |
| Completed | Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis NCT03055507 | University of Washington | Phase 2 / Phase 3 |
| Unknown | Unified Airway Model NCT03937427 | University of British Columbia | — |
| Completed | Adrenaline Solution Irrigation and Bleeding During Sinus Surgery NCT04551703 | Jordan University of Science and Technology | Phase 1 |
| Completed | XprESS Maxillary Balloon Dilation Study NCT01525862 | Entellus Medical, Inc. | N/A |
| Completed | Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis NCT03086070 | Children's Hospital Srebrnjak | Phase 4 |
| Completed | A Study of Different Endoscopic Surgery Procedures in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps NCT03878355 | Beijing Tongren Hospital | N/A |