NCT03559569

Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 520 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease. The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections. The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.

Conditions

• Shock
• Cardiovascular Diseases
• Infection

Interventions

Type	Name	Description
BIOLOGICAL	Biological samples will be done to evaluate the endothelial and leukocyte senescence.	Noninvasive, reproducible, and sensitive methods to measure cardiac function, endothelial function, and arterial stiffness will be assess.

Timeline

• Start date: 2019-01-07
• Primary completion: 2028-02-01
• Completion: 2028-03-01
• First posted: 2018-06-18
• Last updated: 2025-03-10

Locations

1 site across 1 country: France