NCT03554616

Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets

Efficacy of Three Different Bi-treated Long Lasting Insecticidal Nets and Deployment Strategy for Control of Malaria Transmitted by Pyrethroid Resistant Vectors: A Randomised Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4,200 (actual)
• Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
• Sex: All
• Age: 6 Months – 14 Years
• Healthy volunteers: Accepted

Summary

The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries. This progress is threatened by the wide scale selection of insecticide resistant malaria vectors. New types of LLIN combining a mixture of two insecticides or an insecticide and a synergist have been developed to control resistant mosquitoes. The efficacy of three bi-treated LLIN are compared to a standard LLIN in a four-arm, single blinded, cluster-randomized trial in Misungwi district, Tanzania. The arms are; 1/ Royal Guard, a net combining pyriproxyfen (PPF), which is known to disrupt female reproduction and fertility of eggs, and the pyrethroid alpha-cypermethrin, 2/Interceptor G2, LLIN incorporating a mixture of two adulticides with different modes of action; chlorfenapyr and a pyrethroid (alpha-cypermethrin), and 3/ Olyset Plus an LLIN which incorporates a synergist, piperonyl butoxide (PBO), to enhance the potency of pyrethroid insecticides, and 4/ The control arm: Interceptor treated a standard LLIN treated with alpha-cypermethrin. The primary outcome of the trial will be cross-sectional community prevalence of malaria infection (by RDT) in children aged 6 months to 14 years at 12 and 24 months post-intervention.

Conditions

• Malaria
• Anaemia

Interventions

Type	Name	Description
OTHER	Chlorfenapyr LLIN	Dual active ingredient Long Lasting Insecticidal Net
OTHER	pyriproxyfen LLIN	Dual active ingredient Long Lasting Insecticidal Net
OTHER	Piperonyl butoxide LLIN	Combination insecticide and synergist Long Lasting Insecticidal Net
OTHER	Standard LLIN	Standard Long Lasting Insecticidal Net with one insecticide

Timeline

• Start date: 2019-02-01
• Primary completion: 2022-02-28
• Completion: 2023-02-01
• First posted: 2018-06-13
• Last updated: 2024-11-26

Locations

1 site across 1 country: Tanzania