Trials / Terminated
TerminatedNCT03553394
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
The Effects on Fluid Balance and Renal Function Using a Restrictive Fluid Strategy in the Postoperative Setting in Patients With Low Urinary Output Undergoing Pancreatic Surgery
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 53 (actual)
- Sponsor
- Uppsala University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics. However, overloading patients with fluid also have several risks and known complications. Studies have also shown that a short period of decreased urinary output in the postoperative period do not have an increased incidence of acute renal failure. The aim of our study is to investigate the difference in renal function and postoperative complications associated with fluid overload on these patients that are randomized to either receiving a fluid bolus directly when urinary output decreases or to await for a maximum of four hours to see if urinary output increases spontaneously.
Detailed description
Patents after pancreatic surgery will be included in the study. Oliguric patients (urine output \<0.5 ml/kg/h) will be randomized to fluid bolus (5ml/kg Ringer's Acetate in 30 minutes) or no intervention. Primary outcome is difference in urine output two hours after the fluid bolus or no intervention.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Ringer's Acetate | Will receive a fluid bolus immediately (Ringer's Acetate 5 mls/kg bw) if oliguric/anuric for two consecutive hours |
Timeline
- Start date
- 2018-10-01
- Primary completion
- 2021-05-31
- Completion
- 2022-08-30
- First posted
- 2018-06-12
- Last updated
- 2022-10-10
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT03553394. Inclusion in this directory is not an endorsement.