NCT03540680

p16Ink4a in Bronchopulmonary Dysplasia in Children

Case-control Study Evaluating the Impact of p16Ink4a in Bronchopulmonary Dysplasia in Children

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Centre Hospitalier Intercommunal Creteil · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

The bronchopulmonary dysplasia (BPD) is a respiratory disease of the premature child which lead to a reduction of gas exchange surface and to a prolonged respiratory failure. This disease has morphologic and functional consequences at adulthood and is today considered to be an early determinant of respiratory diseases at adulthood. The physiopathology of BPD is not well known. Several mechanisms could be involved especially a reparation failure favored by an increase of cellular senescence which is a permanent stop of cellular proliferation. The transcription factor 16 Ink4a, considered as a marker of aging, is one of the essential markers of senescence. Its increase during prematurity was shown at the blood cells of the cordon, but its involvement in BPD and its evolution in child are not yet studied.

Conditions

• Bronchopulmonary Dysplasia

Interventions

Type	Name	Description
OTHER	Blood punction	For the arms "Term newborns (≥37GA)" and "Premature newborns" the only intervention is a blood punction on the cordon. For the arms "Child between 7 and 15 years old" with or without BPD the only intervention is a blood punction on peripheral blood.

Timeline

• Start date: 2018-03-07
• Primary completion: 2022-03-07
• Completion: 2023-12-30
• First posted: 2018-05-30
• Last updated: 2023-06-07

Locations

1 site across 1 country: France