NCT03537937

Pragmatic Investigation of optimaL Oxygen Targets Trial

Pragmatic Investigation of optimaL Oxygen Targets (PILOT) Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,541 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Mechanical ventilation of ICU patients universally involves titration of the fraction of inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU practice, however, the optimal SpO2 target remains unknown. Current guidelines offer divergent recommendations as to the optimal SpO2 target. Therefore, we propose a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation.

Conditions

• Respiratory Failure

Interventions

Type	Name	Description
OTHER	Lower SpO2 Target	SpO2 target 90% (range 88-92%)
OTHER	Intermediate SpO2 Target	SpO2 target 94% (range 92-96%)
OTHER	Higher SpO2 Target	SpO2 target 98% (range 96-100%)

Timeline

• Start date: 2018-07-01
• Primary completion: 2022-01-31
• Completion: 2022-01-31
• First posted: 2018-05-25
• Last updated: 2023-09-25
• Results posted: 2023-09-25

Locations

1 site across 1 country: United States