NCT03535844

Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults. The investigators hypothesize that consuming wolfberry with a healthy eating pattern diet will contribute to improvements in cardiovascular health when compared to a similar diet without wolfberry.

Detailed description

This is a 16-week parallel, single-blind (investigator), prospective randomized controlled trial. The study was designed based on previous research which showed that consuming 15 g/day of wolfberry for 4 weeks and 14 g/day of wolfberry with meal for 6 weeks increased plasma zeaxanthin concentrations and antioxidant status. Also, other studies reported observable changes in the endothelial progenitor cells and flow mediated dilation after just two weeks of fruit and vegetables or healthy diet interventions. Thus collectively, 16-weeks may be a sufficient period to detect the changes in endothelial function, whole body carotenoids, and anti-oxidant status, which are the outcomes of interest in this research project.

Conditions

• Cardiovascular Diseases
• Aging

Interventions

Type	Name	Description
OTHER	Wolfberry	Consumption of cooked dehydrated wolfberry as part of a mixed meal.
OTHER	Healthy diet	Compliance to a healthy diet in accordance to recommendations by the Singapore Health Promotion Board.

Timeline

• Start date: 2018-08-06
• Primary completion: 2019-09-26
• Completion: 2019-09-26
• First posted: 2018-05-24
• Last updated: 2020-04-22
• Results posted: 2020-04-01

Locations

2 sites across 1 country: Singapore