NCT03530930

Comarum Palustre in Knee Osteoarthritis and Diabetes

Analgesic, Antiinflammatory and Metabolic Effects of Comarum Palustre in Patients With Osteoarthritis and Diabetes Mellitus

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The study evaluates analgesic, antiinflammatory and metabolic effects of Comarum palustre in patients with knee osteoarthritis (OA) and diabetes mellitus. Patients with osteoarthritis will receive Comarum palustre together with conventional treatment of osteoarthritis and diabetes.

Detailed description

Comarum palustre have been shown to exert analgesic properties in patients with knee osteoarthritis not responding to diclofenac. In animal models comarum palustre showed anti-inflammatory, immunomodulatory, analgesic, antioxidant, antihistamine, and membrane-stabilizing effects. Thus, pleiotropic properties of Comarum Palustre may provide a rationale for this use in patients having both osteoarthritis and diabetes mellitus. In this group of patients Comarum Palustre may not only relieve OA-related pain but reduce systemic inflammation, decrease progression of atherosclerosis and diabetes complications.

Conditions

• Osteoarthritis
• Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Comarum Palustre	Comarum Palustre tablets 500 mg BID, 1 month

Timeline

• Start date: 2018-06-29
• Primary completion: 2018-11-25
• Completion: 2018-11-25
• First posted: 2018-05-21
• Last updated: 2019-05-15

Locations

1 site across 1 country: Russia