NCT03517852

Intravital Microscopy (IVM) in Patients With Peritoneal Carcinomatosis (PC)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the tumor-associated vasculature of patients with peritoneal carcinomatosis, or cancer that spreads along the inner abdominal lining. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the tumor-associated vessels of peritoneal disease. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Detailed description

Primary objective(s): To determine the feasibility and clinical utility of performing HIVM in patients with peritoneal carcinomatosis during standard course of treatment (cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, or CRS-HIPEC). Secondary objective(s): 1. Compare the microscopic observation of the tumor-associated vessels with normal tissue (peritoneal surface) in each individual subject. 2. Correlate the microscopic observations of the tumor-associated vessels with pathologic grade of tumor implants. 3. Correlate the microscopic observation of the microvasculature with tumor-specific and overall survival.

Conditions

• Peritoneal Carcinomatosis

Interventions

Type	Name	Description
DEVICE	Human Intravital Microscopy	Intravital microscopy (IVM) allows real-time, direct visualization of microscopic blood vessels and calculation of blood flow.

Timeline

• Start date: 2018-08-15
• Primary completion: 2019-07-23
• Completion: 2023-12-31
• First posted: 2018-05-08
• Last updated: 2024-01-19

Locations

1 site across 1 country: United States